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Another study also showed that 5 mM NAC only slightly mitigated the loss of activity in three cell lines, NCIH2030, A549, and HCC4009, in response to elesclomol (13)

Ectopic expression of OsGSTU4 and OsGSTU30 from rice has been shown to enhance the tolerance of transgenic Arabidopsis thaliana to salinity, oxidative stress, drought, and heavy metal stress [20, 21]

However, perhaps the lack of an effect in these studies is not surprising, given that unlike the studies with healthy cohorts, most volunteers were already receiving vasoactive medications for their respective conditions