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The amyloid precursor protein (APP) undergoes proteolytic cleavage by -secretase to produce A, and APP itself interacts with FPN to regulate iron efflux from neurons (294)

A recent review on glutathione highlights the importance of innovative analogue approaches to overcome poor oral bioavailability, ensuring more effective systemic antioxidant support

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

On the other hand, melatonin has an apoptotic cytotoxic effect on myeloid cell lines HL-60, B lymphoma, MCF-7, prostate cancer cells LNCaP, or hepatocarcinoma HepG2 [43]

In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)

Acrolein can react and form adducts with DNA, lipids and proteins leading to cellular damage in several human tissues