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Glucose metabolism under stress can quickly overwhelm and generate oxidative damage, whereas ketones are a cleaner-burning fuel that mitochondria can use more efficiently

Oct 2017;173:280-285

& De Bono, M

We found that sqst-1(ok2892) increases variation in exopher levels (Supplementary Fig

In molecular dynamics models, it has been discovered that lipid peroxidation induces lipidomic alterations and damages biomembrane characteristics (formation of structured lipid holes, micellization, enhanced permeability, and increased membrane curvature), resulting in cellular dysfunction and death (Hulbert, 2010