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In human growth-hormone-deficiency trials using recombinant native IGF-1 (mecasermin, brand name Increlex), the approved dose range is 0.04-0.12 mg/kg twice daily by subcutaneous injection, titrated to IGF-1 levels in the age- and sex-normalised reference range [15]

[5] As a treatment, once-daily subcutaneous sermorelin (about 30 g/kg at bedtime) increased height velocity in some prepubertal children with idiopathic growth-hormone deficiency, with responses sustained over roughly 12 months and, in a few children, longer

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Consider whether to continue, modify, or begin transitioning to maintenance

Dosing adjusted based on results and symptom response