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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

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The once protected brain is now exposed, which leaves it vulnerable to infections and further injury

Furthermore, the activity of -secretase was attenuated through O-GlcNAcylation at the Ser708 residue of nicastrin (NCT), which is an essential component of the -secretase complex and acts as a substrate receptor 69,70

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