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These included TCA cycle intermediates such as citrate, cis -aconitate, -ketoglutarate, and various amino acids including glutamate, proline, aspartate, asparagine, and alanine as well as glutathione, pyroglutamate, and ornithine

Chronic stress or drug use can simultaneously alter promoter methylation and histone marks to stably repress or activate synaptic genes 177,178,179

Reference Sappl, Carroll, Clifton, Lister, Whelan, Millar and Singh2009

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Cellular responses to oxidative stress: Adaptation, damage, repair, senescence and death

Thao NP, Khan M, Thu N (2015) Role of ethylene and its cross talk with other signaling molecules in plant responses to heavy metal stress