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NAC (N-acetylcysteine)

Introduction Glutathione S -transferases (GSTs) are a family of enzymes that conjugate reduced glutathione (GSH) to target molecules in the phase II detoxification of xenobiotic metabolism ( Here we examined the mechanisms of how GSTM1 regulates astrocyte transcriptional program in response to pro-inflammatory signaling and further addressed the impact of GSTM1 loss-of-function on neurons during acute brain inflammation following a systemic injection of lipopolysaccharides (LPS)

doi: 10.1111/j.1398-9995.2009.01969.x 89 BoehmeSASullivanSKCrowePDSantosMConlonPJSriramaraoPet al

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Dysregulation of this metabolic checkpoint could lead to either excessive synaptic loss or the survival of damaged neurons, contributing to neurodevelopmental or neurodegenerative pathologies