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The main manifestations are behavioral changes and gradual decline of cognitive functions, which seriously affect daily life (Ye et al., 2025)

The emergence of biological and small molecule drugs partially complements the shortcomings of conventional treatment

O.BuschM.WiesnerO.et al

It is logical to begin an analysis of the hormonal interactions with the observation that as the corpus-luteum involutes after a cycle in which conception has not occurred, pituitary FSH release is increased in response to declining estrogen and progesterone concentration

Furthermore, there was an elevation of the Bcl-2 gene, Nrf-2, PPAR-, and HO-1 proteins and a downregulation of the renal gene expression of ATG-5, Keap-1, and NF-B