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13 CNMR (DMSO-d6, 100 MHz ppm) 174.2 (C1), 40.4 (C2), 32.4 (C3), 29.2 (C4), 121.0 (C5), 115.5 (C6), 157.0 (C7), 115.7 (C8), 136.1 (C9), 159.4 (C10), 51.2 (C11) (Figure S10)

Remarkably, the fruit fly Drosophila melanogaster , expresses a GSTE14 with notable steroid isomerase activity, even though Ser14 has evolved as the active-site residue corresponding to Tyr9 in the mammalian alpha class

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This intricate assembly, primarily composed of anaerobic bacteria, encompasses 5001,000 distinct species with a genetic repertoire estimated to surpass the human genome by a factor of 150 (Kho and Lal, 2018

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