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Peer review Peer review information Nature Communications thanks Alison Hulme and the anonymous reviewer(s) for their contribution to the peer review of this work

One such important cell surface protein consisting of highly conserved cysteine residues is connexin 43 (Cx43)a widely expressed gap junctional protein important for cell death, proliferation and differentiation [45]

doi: 10.1039/C7RA13569F 284 de ArajoAASoaresLALFerreiraMRAde Souza NetoMAda SilvaGRde ArajoRFJr.et al

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Univariate analysis indicated that the lymph node status, tumor depth, TNM stage, tumor differentiation, ATF4 expression, and tumor grade were significantly associated with the OS of GC patients ( Table 1 )