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Figure 3 Among them, PRIMA-1 and PRIMA-1Met (APR246, eprenetapopt) have emerged as the first structural reactivators of mutant p53 variants recovering its transcriptional activity by covalent binding cysteines within the core domain (65)

The identified genes are ones known to govern oxidative stress and neuronal ATP levels, suggesting for the first time that mitochondrial genes might be altered in tissue samples from human patients