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(2) the ability to grow in three dimensions (3D) in the absence of intercellular matrix attachment is a necessary hallmark that transforming cells must acquire to develop clinical tumors 33 , and requires quenching an excess of reactive-oxygen species (ROS) 34

However, as with any injectable therapy, certain risks and considerations must be understood and appropriately managed

This underscores the central role of the IGF-1/IGF-1R-PI3K/Akt signaling pathway in the maintenance of skeletal muscle mass