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To clearly illustrate the experimental basis for these findings, Table 1 summarizes key studies supporting the core pathways, including the experimental models used, the CKD stage or modeling approach, and the significant findings

As a RhoGEF, ARHGEF3 exhibits a distinct cellular spatial distribution, primarily localized to the cell membrane and nucleus (Singh et al, 2021)

21 (4), e70103

In vitro helicase unwinding and ATPase assay The truncated C-terminally His-tagged NS3 proteins lacking the protease domain (NS3h) were expressed and purified as described by Hanson et al