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With the antioxidant system overwhelmed by lingering ROS, the cardiovascular and nervous systems remain in a state of high alert, driving the unpredictable symptoms that make patients wonder, "Do Long COVID symptoms come and go?" Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by profound energy deficits and post-exertional malaise (PEM), symptoms directly linked to mitochondrial dysfunction

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doi:10.1111/nbu.12712 Mathew AR, Di Matteo G, La Rosa P, et al

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Copper acts as a catalyst in critical proteins involved in oxidative phosphorylation and antioxidant defenses in the mitochondria