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Different mechanisms, synergistic effects

Proc Natl Acad Sci USA 89 : 69836987 Oscarsson J et al

Tamoxifen activates 50 autophagy and induces apoptosis

The S1 subunit is further divided into an N-terminal domain (NTD) and a RBD (Fig

This is likely to depend on the failure of the autophagy/mitophagy machinery in ATG7 KO, which impedes the membrane elongation process and is inadequate to clear damaged mitochondria