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For example, miR-30a-3p, which is down-regulated in patients with arteriosclerosis obliterans, suppresses vascular smooth muscle cell (VSMC) proliferation, migration, and phenotypic switching by targeting Rho-associated coiled-coil containing protein kinase 2 (ROCK2), thereby delaying neointima formation

The peptide also increases FAK-paxillin signaling involved in cell migration and survival, upregulates GH receptor expression, and interacts with JAK-2 signaling pathways

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Its believed it either works by activating other repair cells that can help tendons or ligaments or making the human growth factor receptor on these cells more sensitive (6)

Liampas I, Siokas V, Brotis A, Vikelis M, Dardiotis E