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FIGURE 2 Curcumin exerts anti-inflammatory effects by targeting key nodes of the NF-B signaling pathway

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Toll-like receptors (TLRs) were increased by TNBS, which resulted in the activation of inflammation-related pathways and the development of intestinal inflammation, while ginger and zingerone inhibited TLR signaling and alleviated TNBS-induced colitis in mice

doi: 10.1016/j.cytogfr.2020.06.001 19 CuiJ.LiF.ShiZ

Cinnamaldehyde-curcumin-BBR formulations (F2) enhance Akt2 phosphorylation (T450, Y475, and S474), improving insulin sensitivity without adipogenic effects in diet-induced obese mice [192, 193]

10.1016/j.neuropharm.2016.09.009 129 MagalonK.ZimmerC.CayreM.KhaldiJ.BourbonC.RoblesI.et al