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Chauhan et al., 2012)

Plasmids For knockdown studies, gene-specific shRNAs were cloned into pLKO.1 vectors (puro/hygro

& Kwong, J

Similarly, H2B monoubiquitination alters chromatin structure, increasing accessibility for transcription and DNA repair, thereby promoting gene activation (Minsky et al., 2008

First, a training set of known compounds belonging to different well-identified mechanisms of toxicity are evaluated in cells

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