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[8] Documented risks Reported adverse events associated with high-dose or injectable glutathione used cosmetically include severe cutaneous reactions (including reports of StevensJohnson syndrome and toxic epidermal necrolysis), potential renal and thyroid dysfunction, abdominal pain, and the infection and embolism risks inherent to any unregulated injectable administered outside proper medical supervision

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Biochemical evidence reliability is of significant importance due to the limitations in the effectiveness of non-invasive localization methods like CT and MRI, as well as the need for specialized imaging modalities and expert staff [70]

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