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Epub 2022 Sep 30

Chronic mild stress (CMS) is widely cited in the literature as a substantial predictor of having a severe depressive episode (134)

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Despite the clear connection between UPR mt activation and longevity in the context of mitochondrial translation inhibition, UPR mt activation is also observed in short-lived mitochondrial mutants, and constitutively active alleles of ATFS-1 exhibit reduced lifespan 15