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However, VEGF released by tumor cells inhibits TNF-a signaling-induced gene expression by interfering with components of the NF-kB pathway (reduction of p-IKKa/b and inhibition of IkB degradation), including T-cells attracting chemokines CXCL10 and CXCL11 and intercellular adhesion molecules [118]

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A 5-primer and 3-primer were synthesised to encompass the sequence of -GCS-HS at positions 105124 and 890909, respectively, as described previously (Morales et al, 1997, 1998)