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Further experiments confirmed that miR-499-5p targets SOX6 , a specific factor known to inhibit the expression of slow-twitch muscle genes, and miR-196-5p targets CALM1 , a key element in the cGMP-PKG and calcium signaling pathways

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At 2 h, 4 h, and 24 h following MTX administration, rats were anesthetized using ether, blood samples were collected from the retro-orbital plexus using a sterile hematocrit capillary, and serum was separated for monitoring MTX levels

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The mechanism by which TMAO causes atherosclerosis will help us design appropriate drugs for optimum cardioprotection and better guide the diet of patients with myocardial infarction or coronary heart disease