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Essentially, proteins synthesized in the cytoplasm must unfold to pass through compact membrane channels to enter organelles, and the process of subsequent refolding requires the assistance of HSP70s

References Li, Y., Xie, H., Deng, Z., Wang, B., Tang, Y., Zhao, Z., Yuan, X., Zuo, Z., Xu, S., Zhang, Y., & Li, J

doi: 10.1177/002215540205000803