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10.1016/j.jacc.2012.09.036 35 LiN.WangW.ZhouH.WuQ.DuanM.LiuC.et al (2020)

PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility

In the first step, the peroxidatic cysteine performs a nucleophilic attack on H 2 O 2 and is partially reduced, resulting in a water molecule and a sulfenic acid intermediate at the N-terminal peroxidatic cysteine