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The treatment efficacy was time dependent with a mild protective effect when applied 4.5 hours after stroke and no effect after 8 hours

Betaine is a methylated derivative of glycine and is a significant methyl donor in OCM (Ducker and Rabinowitz, 2017)

Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3 signaling pathway and alleviates pulmonary arterial hypertension in rats