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There are several indications that only two CCAN components, CENP-C and CENP-N, can interact directly with CENP-A and that the remaining proteins form subcomplexes on this structure ((17) also reviewed in reference 18)

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ERGs, which are used to clinically diagnose retinal diseases, capture the responses of photoreceptors (a-wave), ON-bipolar cells (b-wave), and OFF-bipolar cells (d-wave) (Fig