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Formation of modified DNA bases induces mutagenic properties that could result in binding of transcription factors, alterations in replication of DNA, or appropriate base pairing producing mutations that could lead to altered protein synthesis (55)

Finally, secretion and neurotrophic activity of PEDF under zinc stress conditions were investigated in retinal cells models using various approaches including flow cytometry, confocal microscopy, and targeted liquid chromatographymass spectrometry

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At 3 months, the total glutathione (tGSH), GSH and GSSG levels in the whole homogenate did not significantly differ between mutants and controls

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