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Thus, a remarkable self-sorting behavior of the thiol compounds is demonstrated in this cross-click reaction

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9 Upon activation, IKK phosphorylates IB at two N-terminal serines and, thereby, triggers ubiquitin-dependent IB degradation in the proteasome, resulting in rapid and transient nuclear translocation of canonical NF-B members predominantly the p50/RelA and p50/c-Rel dimers