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2.2 Major exposure pathways and representative cases Human EED exposure occurs through multiple routes, with patterns varying significantly based on occupational activities, environmental conditions, and consumer behaviors

Snails are intermediate hosts

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Field MS, Kamynina E, Watkins D, Rosenblatt DS, Stover PJ (2015) Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis

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Consistently, PLD2-deficient mice were protected against tissue damage and death during experimental sepsis, in association with decreased inflammatory cytokines and chemokines production but increased neutrophil recruitment and bactericidal activity [92]