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Moreover, because MERCs formation serves as an important platform for MITOL-mediated ubiquitination of HMOX2, the effect of MERCs formation on mitochondrial iron homeostasis was assessed by measuring mitochondrial iron levels in PDZD8 KO and VAPB KO cells (Extended Data Fig

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This mechanism is called the carnitine shuttle, in which fatty acids cross the mitochondrial membranes bound to L-carnitine, forming acylcarnitine molecules that can cross the mitochondrial membrane through a transporter in exchange for free L-carnitine

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Unlike whole licorice, DGL extracts provide gastroprotective effects without glycyrrhizin (a component of whole licorice that has been shown to cause side effects such as high blood pressure) (Das 1989