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We use the model system Drosophila, where virtually every gene can be targeted for knock-out or activation in a cell type selective manner Drosophila also offers the advantage that its brain is composed of a relatively small number of stereotyped neuronal lineages, groups of neurons descended from individual embryonic stem cells, called neuroblasts

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in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1659-1679 (Springer, 2022)

Mancini M, Rengo F, Lingetti M, et al

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They may be riskier for large adults