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Tacrolimus is considered a prototype immunomodulatory drug because it inhibits calcineurin synthesis, decreases T-cell activity, and induces the production of proinflammatory cytokines

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NAC enhances extracellular cysteine and by using transport channels increases intracellular cysteine (Franco and Cidlowski, 2009

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In a 2023 review, inositol supplementation was described as an effective and safe treatment in PCOS, with outcomes comparable to metformin in some cases.5 L-Methylfolate (500mcg): Folate has been shown to positively affect glycemic, inflammatory, and oxidative stress markers in women with PCOS.7 It may also support fertility and reproductive outcomes, particularly when combined with other nutrients.67 Wholesome Story uses L-methylfolate (MTHF), the biologically active form of folate, which does not require conversion in the body and is often chosen in reproductive-health formulations.86 Vitamin D3 (1,000 IU): One additional consideration is dosing flexibility