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As a core mechanism in OA pathogenesis, oxidative stress triggers chondrocyte apoptosis and synovial inflammation through the accumulation of ROS, leading to the degeneration and destruction of joint tissues (144)

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Mena FV, Baab PJ, Zielke CL, Huang Y, Zielke HR

Ind Eng Chem Res 48(8):37133729 Kunjapur AM, Prather KL (2015) Microbial engineering for aldehyde synthesis

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Desipramine activates MAPK signaling via ERK1/2 , JNK , and p38 , represses NF-B and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase