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First, targeting of mature OLs without off-targets on the immature stages of the OL lineage may be important, given their differential susceptibilities to injury and responses to extrinsic factors

La gran mayora de los datos proviene de estudios in vivo realizados en modelos murinos y de rata, as como de experimentos in vitro en cultivos celulares

These toxins and oxidative stress damage brain cells and upset the delicate balance of neurotransmitters in the brain, which can cause neurological damage, and in extreme cases, autism

After 3 h of incubation, the cells were washed five times with cold HBSS, and immediately stored at 20 C until analysis

However, their ability to cause severe intestinal and nephrotoxicity initiates burden on the patients life quality

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