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Studies conducted in fruit flies have revealed that grape seed extract attenuates the aggregation of pathologic proteins, which suggests a protective effect against macular degeneration and neurodegenerative disorders

moreover, in humans a higher compliance to a Mediterranean-style diet is related to higher plasma GSH [80]

In addition, efflux transporters such as P -glycoprotein ( P -gp) and breast cancer resistance protein (BCRP) actively remove many therapeutic agents from the brain (Kadry et al., 2020)

For example, Schoonheim et al

Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells

Technological advancements focus on stabilization methods to prevent peptide degradation and encapsulation technologies for enhanced dermal penetration