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ROS generated by NOX4 also damage crucial components of the mitochondrial respiratory chain, further promoting mitochondrial dysfunction, which is a characteristic feature of DCM (79, 80)

Cell 91 , 325334 (1997)

Let your skin breathe and give it time to heal properly

In this DIC model, weight loss, representing emaciation relevant to DOX treatment, was not observed (Figure 1C)

Notably, impairing -glutamylcysteine biosynthesis in the cytosol, but not in mitochondria, still allowed -glutamylcysteine to efficiently detoxify ROS