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This expanded concept is now more commonly known as Developmental Origins of Health and Disease (DOHaD). This theory postulates that adult health is significantly impacted (both positively and negatively) by the fetal environment

Nephrotoxicity is almost certainly secondary to formation of a toxic metabolite, and species differences in the extent of formation of that toxic metabolite could render humans less likely to develop nephrotoxicity and therefore cancer

Using this differentiation system SF-1 was indeed shown to regulate the expression of human alpha class genes in parallel with HSD3B2 (Matsumura et al., 2013)

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This paper reports novel cytokine activities derived from secreted human tyrosyl-tRNA synthetase