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Herbrich S, Ruvolo P, Ruvolo V, Baggerly K, Al-Atrash G, Andreeff M , Konopleva M

In gynecologic oncology, particularly in cervical and endometrial cancers, curcumin may be integrated into combination regimens with chemotherapy, radiotherapy, or hormonal therapies to potentiate treatment responses, mitigate therapy-induced inflammation, and potentially overcome drug resistance through modulation of key signaling pathways such as NF-B, STAT3, and PI3K/Akt

Our results suggest that the pharmacological inactivation of HIF-1, CREB, p53 or NRF2 could be beneficial for the treatment of obesity and type 2 diabetes in humans

Int Tinnitus J 19:1219 Crabb SJ, Martin K, Abab J, Ratcliffe I, Thornton R, Lineton B, Ellis M, Moody R, Stanton L, Galanopoulou A, Maishman T, Geldart T, Bayne M, Davies J, Lamb C, Popat S, Joffe JK, Nutting C, Chester J, Hartley A, Thomas G, Ottensmeier C, Huddart R, King E (2017) COAST (Cisplatin ototoxicity attenuated by aspirin trial): a phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss

Although the total protein level of AMPK remained stable after colchicine treatment, the phosphorylated AMPK level significantly increased in a dose-dependent manner (Fig