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In numerous physiological states, including the neonatal period, fasting, calorie restriction, starvation, post exercise, and very low carbohydrate diets, the body is able to generate ketone bodies (acetoacetate and beta hydroxybutyrate) as an alternative brain energy source to glucose (33)

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Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

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(ME/CFS patients had the highest levels)

To gain further insight into the high reactivity of thiols, it is worth considering Keap1, which acts as a sensor for electrophiles through its highly reactive cysteines, bearing a suitable environment to lower the pKa [60]