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This exhaustion stems from mitochondrial dysfunction: toxins interfere with cellular energy production

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The accumulated crystals can be further enlarged and self-aggregated, leading to the stone formation (Figure 1)

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Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macas D, Bargiela DM, Pietsch S, Gralla M, Evans CE (2018) The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia

There are however many issues that need to be addressed before the COX-2 widespread usage can be recommended in situations where conventional NSAIDs are helpful