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(1986) showed that 10 7 10 3 M GSH or oxidized GSH (GSSG) decreased the affinity of binding sites for [ 3 H]glutamic acid (Glu) through either interacting with synaptic receptors or regulating Glu uptake by central neurons in the rat brain.Citation 19 Afterwards, GSSG but not GSH was shown to selectively attenuate intracellular calcium ([Ca 2+ ]i) and whole-cell currents induced by N-methyl-D-aspartate (NMDA) in rat cortical and retinal ganglion neuron cells

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It was speculated then that an increase of the threshold for voltage activation by high vacuolar Na + can be a mechanism for the prevention of a Na + leak from the vacuole at salt stress (Ivashikina & Hedrich, Reference Ivashikina and Hedrich2005)

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