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Normally brain concentrations of iron are not influenced by circulating iron levels, due to correct functioning of the blood-brain barrier and blood-cerebrospinal fluid barrier

have reported that the existence of Cu-A complexes reduce the expression of LRP1 (lipoprotein receptor-related protein 1), further reducing the clearance of neurotoxic A and increasing brain A deposits

Low iron stores may influence dopaminergic and serotonergic signaling, affecting emotional regulation

The elimination of toxins is done through a two-step enzymatic process

Berrens, R