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Unfortunately, these features are not failproof, and some individuals with LS will present with metastatic disease, which is associated with poorer outcomes [106]

Curr Opin Obstet Gynecol 25:167172

Digestive Disorders Health Center: Bilirubin

4e), the pyruvyl moiety makes hydrogen bonds with residues His193, Asn313, Ser315, Ser317, Thr347, and a water molecule, as well as a covalent linkage with Cys191, resulting in an ICL1-inhibitor covalent adduct

The cytosolic FeS assembly pathway (CIA) consists of 8 proteins of which 7 are conserved in plants

These diseases result from losing neurons or their myelin sheaths, worsening and leading to functional impairments [5, 6]