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Metabolic disorders are very inheritable, and researchers have identified genetic variations on genes involved with carnitine production, among other things

Similarly, another in vitro study found that TMAO can also upregulate the NF-B signaling pathway to promote adipogenic differentiation and inhibit the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) (59)

There, fatty acids undergo oxidation or combustion for energy production

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The author recommends L-carnitine (100 mg/kg/d divided BID), coenzyme Q10 (4 mg/kg/day), and supplementation with B vitamins

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