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The late luteal phase shows increased cytokine expression that leads to luteal cell apoptosis and vascular regression to facilitate luteolysis (155, 156)

Combined BRAF and MEK inhibitors, as compared with BRAF inhibition alone, provided remarkable response rates in melanoma, delayed the emergence of resistance, and reduced toxic effects in patients with BRAF V600E -mutated melanoma ( V600E -mutated melanoma cell lines (conventional and PDCLs) responded distinctively to PLX4032 (also known as RG7204 or RO5185426) ( V600E mutant cells

Thus, these data, for the first time, provide a novel therapy for DED treatment and elaborate a better understanding of its pathogenesis

doi:10.7150/ijbs.18636 48

Long-chain acyl-CoA synthetase family member 4 (ACSL4) facilitates the incorporation of PUFAs, including arachidonate and adrenate, into cellular membranes (82)

Diabetes was then chemically induced in C57BL/6 mice