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10.1073/pnas.1303819110 11 BhattiJ

In this case, mutation of Cys174 to serine significantly inhibits ADH5 supersulfidation and abolishes its S-nitrosoglutathione reductase activity, causing an enhancement in NO signaling

To date, it has been used in multiple cell lines such as cervical cancer, glioma, thyroid cancer, renal cancer, bladder cancer and gastric cancer cells.In cervical cancer research, treatment of HeLa cervical cancer cells with the product significantly inhibits cancer cell proliferation in a concentration and timedependent manner

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However, resveratrol pretreatment can down-regulate the expression of cyclooxygenase (COX)-2 and its metabolite prostaglandin E2 (PGE2), inhibit oxidative stress, and reduce the activity of these inflammatory pathways