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Additionally, SIRT2 increases the deacetylation level of c-Jun/c-Fos and increases the binding activity of AP-1 and the inflammatory factor MCP-1, thereby aggravating the HG/PA-induced inflammatory response ( Although many agonists or inhibitors have shown significant efficacy for kidney diseases in preclinical studies, the use of most agonists and inhibitors in kidney diseases remains controversial (Hyndman, 2020