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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

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ALS and Dystrophic Muscle Models MGF E-peptide was shown to increase progenitor cell populations in ALS (amyotrophic lateral sclerosis), dystrophic, and normal rodent muscle establishing a research application in neuromuscular disease models beyond straightforward exercise-induced muscle damage