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Congruent with our result, Regland et al

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In diabetic cardiomyopathy (DCM), a range of pathological processes occurs, including increased oxidative stress, mitochondrial dysfunction, impaired cardiac insulin signaling, reduced nitric oxide (NO) bioavailability, impaired calcium handling in both mitochondria and cardiomyocytes, cardiac autonomic neuropathy, activation of the renin-angiotensin-aldosterone system, inflammation, and microvascular dysfunction [25]

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