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Among 17 members in humans and 16 members in mice, PARP1 alone is responsible for about 90% of all NAD + used by the PARP protein family [49]

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The effect was most pronounced for old RBC when experimentally evoked by a hyperosmotic shock, such that PS exposure increased 10-fold by 4 weeks storage and more so in old RBC (Bosman et al., 2011)